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  • You Are What You Eat (Human or Chimp)

    Sharon Begley | Jan 29, 2008 08:00 PM

    By all rights, chimps and humans should be a lot more similar than we are, considering that our DNA sequences are just under 99 percent identical. But as geneticists keep discovering, just as which music you hear depends not only on what you’ve loaded onto your iPod but also on which tunes you actually play, so what matters in DNA isn’t so much which genes you have as which ones are expressed.

    Curiously, scientists now report, which genes are expressed depends, at least in part, on what you eat.

    We humans eat much more meat and fat than chimps do, and also cook our food. Researchers at the Max Planck Institute for Evolutionary Anthropology in Germany therefore fed laboratory mice different human and chimp diets for two weeks. The mice ate raw fruits and vegetables like chimpanzees in zoos get, or a human diet of food from the Institute cafeteria, or a pure fast food menu from the local McDonald’s.

    Result: the different diets led to remarkable changes in which of the mouse genes were turned on, the scientists report this evening in the journal PLoS ONE. There were thousands of differences in the levels at which genes were expressed in the mouse livers but, interestingly, not in the mouse brains. Many of the genes that changed in the mouse livers are known to differ between humans and chimpanzees, suggesting that these differences might be caused by the difference in human and chimpanzee diets.

    Obviously what you eat doesn’t determine which species you are (though we know some vegans who are looking a little simian lately). The scientists calculate that diet accounts for expression differences of 4 percent to 8 percent in the mice’s liver genes, whereas the amount of expression difference between humans and chimpanzees is 15 percent. But it is one more clue to how such small genetic differences can produce species are different as chimps and people.

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  • Believing 3 Ridiculous Things Before Breakfast

    Sharon Begley | Jan 29, 2008 02:42 PM

    Lots has been written about why people believe things that fit their worldview even when those things have been disproved time and again (Iraqi weapons of mass destruction, anyone?). But there is a more benign form of this pathology, in which people would rather believe a “good story” than know whether it’s true or not.

    This hit me when a friend emailed a film clip of what purports to be a charming music machine, built at the University of Iowa. To me, it looked computer generated, and indeed about three seconds of searching showed that it was yet another urban legend. The surprising part was how the sender, as well as those I had passed it on to myself, reacted when I pointed this out.

    The essence was, “thanks a lot for bursting my bubble. I enjoyed it a lot and wanted other people to enjoy it, too. Now you’ve ruined it.”

    What struck me about this was that intelligent, science-aware people want to believe cute stories, and are disappointed (even irate) if “science” (me) points out that the story isn’t true. The attitude is, “Who cares if it’s true?”

    There seems to be a near-universal human need to hear (and tell, and believe) a good story, regardless of its truth. I’ll leave it to you to think how this can be exploited by, among others, prosecutors (by telling a more compelling story, they can lead juries to convict the innocent) and by cynical and manipulative political leaders.

    But here’s one hint. In a 2005 study, scientists found that what you remember and believe about events during the Iraq war depends on your political views. Do you recall a suicide bomber nearing a Najaf checkpoint and blowing up U.S. soldiers? The execution of coalition POWs by Iraqis? The civilian uprising in Basra against Saddam’s Baathist party? All were initially reported by the press, but the last two were quickly retracted as being products of the fog of war.

    Yet Americans (especially those who supported the invasion) tend to believe that the last two events occurred even when they recall the retraction. Germans and Australians who recall the retraction, in contrast, no longer believe the misinformation. “People build mental models,” Stephan Lewandowsky, a psychology professor at the University of Western Australia, Crawley, who led the study told me in 2005. “By the time they receive a retraction, the original misinformation has already become an integral part of that mental model, or world view, and disregarding it would leave the world view a shambles.” People therefore “continue to rely on misinformation even if they demonstrably remember and understand a subsequent retraction,” he and colleagues wrote.

    The late New York Sen. Patrick Moynihan famously said that people are entitled to their own opinions, but not to their own facts. Believing in the magical music machine is obviously of less concern than believing erroneous information about the Iraq war. But the two beliefs show that people who care about facts are working against powerful elements of human nature. If a “good story” trumps the facts much of the time with many people, we are in deep trouble.

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